Across TCGA pan-cancer cohorts, LCE1D RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LCE1D’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LCE1D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LCE1D is over-expressed in tumor.
LUSC and KIRC are the cancer types where LCE1D tumor–normal differential expression is most reproducible.