Across TCGA pan-cancer cohorts, LCE1A Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated LCE1A data layer compared with 16 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LCE1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LCE1A expression acts as an unfavorable survival marker.

HNSC are the cancer types where LCE1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.145	0.661	<.001	27	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: LCE1A tumor-vs-normal RNA expression · all LCE1A data types