LBX1

Across TCGA patient cohorts, LBX1 mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LBX1-associated genes across cancer lineages are MTND2P19, SNORD31B, and MIR548AD. Each is linked with LBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LBX1-to-partner and partner-to-LBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND2P19 grouped by LBX1-low versus LBX1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LBX1→partner) and Y-score (partner→LBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTND2P19 →	+0.052	+5.410	<.001	.005	3	2
STAD	SNORD31B →	+0.341	+3.736	.007	.008	3	2
STAD	MIR548AD →	+0.322	+4.815	<.001	.004	3	2
LUSC	MIR1252 →	+0.569	+4.984	<.001	.009	3	2
LUSC	RPS29P33 →	+0.540	+6.309	<.001	.001	3	2
HNSC	RNU6-1032P →	+0.233	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

MTND2P19 by LBX1 expression — LUAD

Explore this box plot interactively →