LBX1

Across TCGA pan-cancer cohorts, LBX1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LBX1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where LBX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LBX1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

BLCA, HNSC, and LUAD are the cancer types where LBX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LBX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.612	.040	3	view →
HNSC	Male	All	−0.351	.040	1	view →
LUAD	All	All	−0.065	.041	1	view →
THCA	Female	III,IV	+0.012	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

LBX1–BLCA

Open the BLCA breakdown →