LBX1

Across TCGA cell cohorts, LBX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,430 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LBX1-associated GO terms across cancer lineages are DNA-templated transcription initiation, Binding of sperm to zona pellucida, and Inorganic cation import across plasma membrane. Each is linked with LBX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LBX1-to-partner and partner-to-LBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by LBX1-low versus LBX1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LBX1→partner) and Y-score (partner→LBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.060	+0.051	<.001	.001	3	5
SOFT_TISSUE	Binding of sperm to zona pellucida →	+0.114	+0.831	<.001	<.001	3	5
SOFT_TISSUE	Inorganic cation import across plasma membrane →	-0.035	-0.637	.009	.004	3	5
SOFT_TISSUE	Inorganic ion import across plasma membrane →	-0.035	-0.637	.009	.004	3	5
LUNG_SCLC	Regulation of cardiac muscle cell contraction →	-0.099	-0.765	<.001	.001	3	5
SOFT_TISSUE	Positive regulation of mitotic cell cycle phase transition →	+0.078	+0.791	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,430 associations by consensus.

DNA-templated transcription initiation by LBX1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →