LBP

Across TCGA patient cohorts, LBP mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LBP-associated genes across cancer lineages are XBP1, JNK2, and Notch1. Each is linked with LBP in more than 1 cancer types. Because this analysis shows association rather than direction, both LBP-to-partner and partner-to-LBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by LBP-low versus LBP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LBP→partner) and Y-score (partner→LBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	XBP1 →	-0.272	-2.321	.026	.035	3	2
UCEC	JNK2 →	+0.221	+2.834	.013	.034	3	1
UCEC	Notch1 →	+0.164	+3.013	.009	.018	3	1
UCEC	p62 Lck ligand →	+0.405	+2.000	.005	.032	3	1
UCEC	PKC-a →	+0.445	+3.169	.014	.019	3	1
UCEC	VEGFR2 →	+0.380	+2.321	.004	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

XBP1 by LBP expression — SKCM

Explore this box plot interactively →