LBP

Across TCGA cell cohorts, LBP mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LBP-associated genes across cancer lineages are HSF5, APOL5, and CLEC4E. Each is linked with LBP in more than 1 cancer types. Because this analysis shows association rather than direction, both LBP-to-partner and partner-to-LBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSF5 grouped by LBP-low versus LBP-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LBP→partner) and Y-score (partner→LBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HSF5 →	+0.006	+5.000	<.001	.005	3	1
SKIN	APOL5 →	+0.070	+3.345	<.001	.007	3	1
SKIN	CLEC4E →	+0.093	+3.347	<.001	.005	3	1
SKIN	ACTL9 →	+0.016	+4.022	<.001	.006	3	1
SKIN	C1QTNF8 →	+0.068	+3.345	<.001	.007	3	1
SKIN	DIO3 →	+0.268	+4.064	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

HSF5 by LBP expression — KIDNEY

Explore this box plot interactively →