Across TCGA patient cohorts, LAYN mutation is significantly associated with the RNA expression of many other genes, with 959 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAYN-associated genes across cancer lineages are RRP12, RPS12P15, and RNY4P9. Each is linked with LAYN in more than 1 cancer types. Because this analysis shows association rather than direction, both LAYN-to-partner and partner-to-LAYN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAYN→partner) and Y-score (partner→LAYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRP12 →	+0.394	+3.470	.009	.002	3	2
COAD	RPS12P15 →	+0.148	+4.693	<.001	.007	3	2
BRCA	RNY4P9 →	+0.373	+5.070	<.001	.008	3	2
LUSC	RNA5SP426 →	+0.318	+7.924	<.001	.008	3	2
SKCM	RNU6-1250P →	+0.128	+4.039	<.001	.009	3	2
BLCA	SNORD109B →	+0.510	+5.722	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 959 associations by consensus.

Exploration

LAYN survival (RNA) · tumor vs normal (RNA) · all LAYN data types