LAX1

Across TCGA cell cohorts, LAX1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LAX1-associated genes across cancer lineages are ADAM7, GHRHR, and H2BC1. Each is linked with LAX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAX1-to-partner and partner-to-LAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by LAX1-low versus LAX1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAX1→partner) and Y-score (partner→LAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADAM7 →	+0.035	+4.922	<.001	.009	3	2
SOFT_TISSUE	GHRHR →	+0.521	+3.865	<.001	.006	3	1
SOFT_TISSUE	H2BC1 →	+0.260	+4.392	<.001	.004	3	1
SOFT_TISSUE	H2AC1 →	+0.115	+4.392	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.052	+4.392	<.001	.004	3	1
SOFT_TISSUE	HNRNPCL3 →	+0.141	+3.865	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ADAM7 by LAX1 expression — BLOOD_Leukemia

Explore this box plot interactively →