LAX1

Across TCGA pan-cancer cohorts, LAX1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LAX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LAX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LAX1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where LAX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LAX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.126	<.001	10	view →
COAD	Female	III,IV	−1.495	<.001	8	view →
KICH	All	All	−0.515	.004	4	view →
LUAD	All	All	+0.617	<.001	3	view →
HNSC	All	III,IV	+0.487	.022	2	view →
UCEC	All	All	−0.252	.044	2	view →
ESCA	All	All	+1.213	.026	1	view →
THCA	All	All	−0.474	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

LAX1–KIRC

Open the KIRC breakdown →