LATS2-AS1

Across TCGA pan-cancer cohorts, LATS2-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated LATS2-AS1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher LATS2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LATS2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

THCA, KIRC, and KICH are the cancer types where LATS2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	III,IV	0.753	0.951	<.001	117	view →
KIRC	OS	Median	All	0.492	0.696	<.001	108	view →
KICH	OS	Tertile	All	0.752	0.981	.013	36	view →
LIHC	DFS	Tertile	All	0.339	0.554	.007	36	view →
KIRP	OS	Tertile	II,III,IV	0.647	0.898	.006	30	view →
UCEC	DFS	Tertile	II,III,IV	0.751	0.835	.019	30	view →
READ	DFS	Tertile	All	0.178	0.576	.002	27	view →
TGCT	DFS	Tertile	III,IV	0.505	1.000	.016	18	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
LGG	OS	Tertile	All	0.180	0.467	.020	12	view →
LUAD	DFS	Tertile	III,IV	0.870	0.429	.020	12	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

LATS2-AS1–THCA (DFS)

Open the THCA breakdown →