LATS1

Across TCGA pan-cancer cohorts, LATS1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated LATS1 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LATS1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated LATS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, COAD, and PAAD are the cancer types where LATS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.979	0.824	.003	32	view →
COAD	OS	Median	II,III,IV	0.363	0.869	<.001	28	view →
PAAD	OS	Median	All	0.028	0.614	<.001	24	view →
LUAD	OS	Median	All	0.331	0.679	.005	20	view →
BLCA	DFS	Median	All	0.147	0.598	.003	15	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	6	view →
OV	DFS	Median	IV	0.100	0.464	.044	6	view →
SCLC	OS	Median	All	0.082	0.822	<.001	6	view →
STAD	OS	Median	II,III,IV	0.153	0.566	.013	6	view →
HNSC	DFS	Median	IV	0.147	0.583	.006	6	view →
SKCM	DFS	Median	All	0.429	0.625	.037	5	view →
ESCA	DFS	Median	All	0.195	0.535	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

LATS1–UCEC (DFS)

Open the UCEC breakdown →