LATS1

Across TCGA patient cohorts, LATS1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LATS1-associated genes across cancer lineages are Cyclin-B1, eIF4E, and FoxM1. Each is linked with LATS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LATS1-to-partner and partner-to-LATS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by LATS1-low versus LATS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LATS1→partner) and Y-score (partner→LATS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.736	+3.087	<.001	<.001	3	4
UCEC	eIF4E →	+0.191	+3.598	.004	.001	3	3
UCEC	FoxM1 →	+0.268	+2.058	.001	<.001	3	3
UCEC	RAD51 →	+0.090	+1.584	.042	.034	3	3
UCEC	ATM →	-0.480	-2.058	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.444	+1.697	.019	.012	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Cyclin-B1 by LATS1 expression — UCEC

Explore this box plot interactively →