LATS1

Across TCGA cell cohorts, LATS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,276 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LATS1-associated GO terms across cancer lineages are Termination of RNA polymerase II transcription, Nuclear transport, and Nucleocytoplasmic transport. Each is linked with LATS1 in more than 19 cancer types. Because this analysis shows association rather than direction, both LATS1-to-partner and partner-to-LATS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase II transcription grouped by LATS1-low versus LATS1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LATS1→partner) and Y-score (partner→LATS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Termination of RNA polymerase II transcription →	+0.147	+0.879	<.001	<.001	3	20
BLOOD_Myeloma	Nuclear transport →	+0.081	+1.115	.001	.001	3	19
BLOOD_Myeloma	Nucleocytoplasmic transport →	+0.081	+1.115	.001	.001	3	19
BREAST	DNA-templated transcription initiation →	+0.060	+0.889	.001	<.001	3	19
OVARY	Regulation of nucleotide-excision repair →	+0.117	+0.740	<.001	<.001	3	18
URINARY_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.081	+0.977	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,276 associations by consensus.

Termination of RNA polymerase II transcription by LATS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →