LATS1

Across TCGA cell cohorts, LATS1 mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LATS1-associated genes across cancer lineages are SLC25A3, IFNA8, and SPRR3. Each is linked with LATS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LATS1-to-partner and partner-to-LATS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A3 grouped by LATS1-low versus LATS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LATS1→partner) and Y-score (partner→LATS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC25A3 →	+0.372	+2.158	.007	.004	3	2
SOFT_TISSUE	IFNA8 →	+0.052	+4.930	<.001	.008	3	1
SOFT_TISSUE	SPRR3 →	+0.061	+4.930	<.001	.008	3	1
SOFT_TISSUE	TEX55 →	+0.026	+5.369	<.001	.004	3	1
SOFT_TISSUE	GP9 →	+0.026	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

SLC25A3 by LATS1 expression — LARGE_INTESTINE

Explore this box plot interactively →