Q-omics provides the consensus-scored LASTR profile across patient tissues and cancer cell-line models. LASTR expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, LASTR is differentially expressed in 16, with the highest sampling consensus in HNSC. Additionally, LASTR RNA expression shows 10,969 significant gene co-expression associations, with the highest sampling consensus in ESCA. Together, these results highlight KIRC, HNSC, and ESCA as cancer lineages where LASTR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LASTR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LASTR survival associations across molecular data types. LASTR RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LASTR RNA expression–survival associations across cancer types. High LASTR expression shows unfavorable associations in KIRC, HNSC, UVM, MESO, STAD and LIHC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for LASTR RNA expression.
This table summarizes LASTR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for LASTR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LASTR shows higher tumor expression in HNSC, BLCA, LUAD, COAD, LUSC and KIRC. The HNSC box plot shows higher LASTR RNA expression in tumor versus normal tissue (log2 FC = +2.963, t-test p < 0.001).
This table shows molecular features associated with LASTR in patient tissues and cancer cell lines. In patient samples, LASTR shows the broadest associations at the RNA and protein expression levels, with ESCA recurring as the lineage with the largest associated feature set.
