LAS1L

Across TCGA patient cohorts, LAS1L protein abundance is significantly associated with the RNA expression of many other genes, with 21,640 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LAS1L-associated genes across cancer lineages are TEX10, DARS2, and CCRL2. Each is linked with LAS1L in more than 7 cancer types. Because this analysis shows association rather than direction, both LAS1L-to-partner and partner-to-LAS1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LAS1L versus TEX10 in LSCC, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAS1L→partner) and Y-score (partner→LAS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TEX10 →	+0.665	+0.378	<.001	<.001	3	8
LSCC	DARS2 →	+0.828	+0.384	<.001	<.001	3	7
UCEC	CCRL2 →	-0.892	-0.213	<.001	.001	3	7
COAD	SUV39H1 →	+0.546	+0.156	.006	.005	3	7
LSCC	RPS10 →	+0.503	+0.221	<.001	<.001	3	7
LSCC	POLR1B →	+0.660	+0.338	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,640 associations by consensus.

LAS1L vs TEX10 — LSCC

Explore this scatter interactively →