LAS1L

Across TCGA patient cohorts, LAS1L mutation is significantly associated with the RNA expression of many other genes, with 3,065 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAS1L-associated genes across cancer lineages are UHRF1, RNA5SP384, and HROB. Each is linked with LAS1L in more than 2 cancer types. Because this analysis shows association rather than direction, both LAS1L-to-partner and partner-to-LAS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by LAS1L-low versus LAS1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAS1L→partner) and Y-score (partner→LAS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.815	+2.061	<.001	<.001	3	3
SKCM	RNA5SP384 →	+0.149	+3.452	<.001	.004	3	3
SKCM	HROB →	+0.794	+3.208	<.001	.009	3	3
SKCM	SLC25A39 →	+0.454	+3.217	.007	.009	3	3
UCEC	SKA1 →	+0.698	+2.332	<.001	<.001	3	3
UCEC	THOP1 →	+0.519	+1.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,065 associations by consensus.

UHRF1 by LAS1L expression — UCEC

Explore this box plot interactively →