LARP4B

Across TCGA patient cohorts, LARP4B mutation is significantly associated with the RNA expression of many other genes, with 4,752 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARP4B-associated genes across cancer lineages are HJURP, KIF11, and MKI67. Each is linked with LARP4B in more than 3 cancer types. Because this analysis shows association rather than direction, both LARP4B-to-partner and partner-to-LARP4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HJURP grouped by LARP4B-low versus LARP4B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP4B→partner) and Y-score (partner→LARP4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HJURP →	+0.790	+3.478	<.001	.002	3	4
SKCM	KIF11 →	+0.833	+3.469	.001	.002	3	4
SKCM	MKI67 →	+0.738	+2.913	.002	.001	3	4
SKCM	BUB3 →	+0.581	+2.913	<.001	.001	3	4
UCEC	PKN3 →	+0.712	+1.776	<.001	<.001	3	4
UCEC	UBE2T →	+0.660	+2.212	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,752 associations by consensus.

HJURP by LARP4B expression — SKCM

Explore this box plot interactively →