LARP4B

Across TCGA pan-cancer cohorts, LARP4B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LARP4B data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher LARP4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LARP4B expression acts as an unfavorable survival marker, although some lineages such as LGG and HNSC show a favorable association.

ACC, LIHC, and CESC are the cancer types where LARP4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.239	0.670	<.001	100	view →
LIHC	DFS	Median	All	0.452	0.623	<.001	98	view →
CESC	DFS	Tertile	III,IV	0.266	0.748	<.001	66	view →
BLCA	DFS	Tertile	All	0.166	0.519	<.001	46	view →
LGG	OS	Median	All	0.934	0.853	<.001	33	view →
UVM	DFS	Quartile	II,III,IV	0.264	0.780	.003	30	view →
KIRP	DFS	Tertile	III,IV	0.187	0.686	.015	30	view →
HNSC	DFS	Median	All	0.767	0.650	.006	24	view →
THYM	DFS	Median	II,III,IV	0.887	0.562	.002	22	view →
BRCA	OS	Quartile	II,III,IV	0.525	0.734	.002	20	view →
UCEC	OS	Tertile	IV	0.705	0.280	.029	14	view →
LUSC	OS	Quartile	II,III,IV	0.700	0.462	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LARP4B–ACC (DFS)

Open the ACC breakdown →