LARP4B

Across TCGA patient cohorts, LARP4B mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARP4B-associated genes across cancer lineages are eIF4E, PCNA, and RAD51. Each is linked with LARP4B in more than 2 cancer types. Because this analysis shows association rather than direction, both LARP4B-to-partner and partner-to-LARP4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LARP4B-low versus LARP4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP4B→partner) and Y-score (partner→LARP4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.214	+1.807	<.001	<.001	3	3
COAD	PCNA →	+0.266	+2.178	.022	.035	3	2
COAD	RAD51 →	+0.199	+3.330	.007	.005	3	2
COAD	Caspase-7-cleavedD198 →	+1.005	+3.000	.006	.035	2	3
COAD	c-Kit →	-0.840	-3.313	.002	.010	3	2
UCEC	FASN →	+0.240	+1.184	.041	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eIF4E by LARP4B expression — UCEC

Explore this box plot interactively →