LARP4B

Across TCGA cell cohorts, LARP4B mutation is significantly associated with the RNA expression of many other genes, with 1,174 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LARP4B-associated genes across cancer lineages are JOSD1, C12orf57, and DCLRE1B. Each is linked with LARP4B in more than 1 cancer types. Because this analysis shows association rather than direction, both LARP4B-to-partner and partner-to-LARP4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JOSD1 grouped by LARP4B-low versus LARP4B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP4B→partner) and Y-score (partner→LARP4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JOSD1 →	+0.536	+2.850	.001	<.001	3	2
LARGE_INTESTINE	C12orf57 →	+0.731	+2.158	.003	.004	3	2
LARGE_INTESTINE	DCLRE1B →	+0.476	+2.158	.005	.004	3	2
LARGE_INTESTINE	NFE2 →	-0.960	-3.584	.007	<.001	3	2
LARGE_INTESTINE	GAREM1 →	+0.619	+2.850	.001	<.001	3	2
LARGE_INTESTINE	CELSR2 →	+0.714	+3.169	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,174 associations by consensus.

JOSD1 by LARP4B expression — LARGE_INTESTINE

Explore this box plot interactively →