LARP4

Across TCGA patient cohorts, LARP4 mutation is significantly associated with the RNA expression of many other genes, with 1,695 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARP4-associated genes across cancer lineages are TYRP1, KRT18P5, and RMDN3. Each is linked with LARP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARP4-to-partner and partner-to-LARP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYRP1 grouped by LARP4-low versus LARP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP4→partner) and Y-score (partner→LARP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYRP1 →	-0.348	-2.611	.006	<.001	3	3
UCEC	KRT18P5 →	+0.270	+3.151	<.001	<.001	3	3
SKCM	RMDN3 →	+0.412	+3.370	.009	.004	3	3
COAD	RNU6-784P →	+0.195	+3.101	<.001	.008	3	2
COAD	MIR30B →	+0.242	+3.707	<.001	.002	3	2
COAD	KCNIP2-AS1 →	+0.406	+3.335	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,695 associations by consensus.

TYRP1 by LARP4 expression — UCEC

Explore this box plot interactively →