LARP1B

Across TCGA patient cohorts, LARP1B mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARP1B-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and eEF2. Each is linked with LARP1B in more than 1 cancer types. Because this analysis shows association rather than direction, both LARP1B-to-partner and partner-to-LARP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LARP1B-low versus LARP1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARP1B→partner) and Y-score (partner→LARP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.684	+2.090	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.087	-2.195	.004	.009	3	1
UCEC	eEF2 →	+0.283	+1.473	.009	.006	3	1
UCEC	EGFR_pY1068 →	-0.296	-2.999	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.109	-1.765	.002	.013	3	1
UCEC	ERK2 →	+0.208	+2.415	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by LARP1B expression — UCEC

Explore this box plot interactively →