LARGE2

Across TCGA patient cohorts, LARGE2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,831 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible LARGE2-associated proteins across cancer lineages are ACTL6A, CELF1, and BTK. Each is linked with LARGE2 in more than 5 cancer types. Because this analysis shows association rather than direction, both LARGE2-to-partner and partner-to-LARGE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LARGE2 versus ACTL6A in GBM, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE2→partner) and Y-score (partner→LARGE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACTL6A →	+0.256	+0.294	<.001	.007	3	6
LSCC	CELF1 →	+0.225	+0.647	.004	.008	3	6
CCRCC	BTK →	-0.399	-0.762	.001	.003	3	5
COAD	DHX9 →	+0.195	+1.245	<.001	<.001	3	5
LSCC	FMNL1 →	-0.435	-0.838	<.001	<.001	3	5
CCRCC	ALOX5 →	-0.508	-0.796	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,831 associations by consensus.

LARGE2 vs ACTL6A — GBM

Explore this scatter interactively →