LARGE2

Across TCGA patient cohorts, LARGE2 mutation is significantly associated with the RNA expression of many other genes, with 984 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARGE2-associated genes across cancer lineages are RNU7-161P, GAGE2E, and MIR7975. Each is linked with LARGE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARGE2-to-partner and partner-to-LARGE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-161P grouped by LARGE2-low versus LARGE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE2→partner) and Y-score (partner→LARGE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU7-161P →	+0.155	+2.847	.007	.008	3	3
GBM	GAGE2E →	+0.476	+5.584	<.001	.003	3	2
GBM	MIR7975 →	+0.770	+5.857	<.001	.002	3	2
GBM	CYCSP35 →	+0.228	+5.352	<.001	.005	3	2
READ	MTND4P7 →	+0.509	+6.681	<.001	<.001	3	2
READ	RN7SL612P →	+0.520	+5.219	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 984 associations by consensus.

RNU7-161P by LARGE2 expression — UCEC

Explore this box plot interactively →