LARGE2

Across TCGA cell cohorts, LARGE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,191 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LARGE2-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Cytotoxic T cell degranulation, and Negative regulation of RNA catabolic process. Each is linked with LARGE2 in more than 9 cancer types. Because this analysis shows association rather than direction, both LARGE2-to-partner and partner-to-LARGE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by LARGE2-low versus LARGE2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE2→partner) and Y-score (partner→LARGE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.120	+2.133	<.001	<.001	3	10
BONE	Cytotoxic T cell degranulation →	+0.307	+2.028	<.001	<.001	3	10
LIVER	Negative regulation of RNA catabolic process →	+0.060	+2.417	.001	.001	3	9
LIVER	Negative regulation of mRNA catabolic process →	+0.081	+2.906	.001	<.001	3	9
LUNG_NSCLC_LUSC	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.232	+2.945	<.001	<.001	3	9
OVARY	Establishment of epithelial cell apical/basal polarity →	-0.241	-2.388	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,191 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by LARGE2 expression — OVARY

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