LARGE-IT1

Across TCGA patient cohorts, LARGE-IT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,676 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LARGE-IT1-associated proteins across cancer lineages are CASP4, PTPN12_S435, and RBM15B. Each is linked with LARGE-IT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LARGE-IT1-to-partner and partner-to-LARGE-IT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LARGE-IT1 versus CASP4 in GBM, with a Pearson correlation of -0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE-IT1→partner) and Y-score (partner→LARGE-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CASP4 →	-0.497	-0.486	<.001	<.001	3	3
GBM	PTPN12_S435 →	-0.641	-0.470	<.001	.002	3	3
GBM	RBM15B →	+0.299	+0.613	<.001	<.001	3	3
GBM	CENPV →	+0.718	+0.571	.006	<.001	3	3
CCRCC	HDGFL3 →	+0.556	+0.423	<.001	<.001	3	3
CCRCC	MAP2_T1649 →	+0.953	+0.334	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,676 associations by consensus.

LARGE-IT1 vs CASP4 — GBM

Explore this scatter interactively →