LARGE-IT1

Across TCGA pan-cancer cohorts, LARGE-IT1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated LARGE-IT1 data layer.

The strongest signal is observed in thymoma (THYM), where higher LARGE-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LARGE-IT1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

THYM, DLBC, and SKCM are the cancer types where LARGE-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.133	0.888	<.001	90	view →
DLBC	OS	Tertile	II,III,IV	0.430	0.895	.001	72	view →
SKCM	DFS	Tertile	II,III,IV	0.584	0.241	.005	39	view →
CHOL	OS	Tertile	All	0.024	0.675	<.001	36	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
CESC	DFS	Tertile	II,III,IV	1.000	0.401	.008	30	view →
COAD	OS	Tertile	IV	0.045	0.659	<.001	18	view →
ACC	DFS	Tertile	III,IV	0.048	0.457	.015	18	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	18	view →
LAML	DFS	Median	All	0.574	0.354	.025	8	view →
THCA	OS	Tertile	All	0.598	0.958	.034	6	view →
OV	OS	Tertile	IV	0.546	0.838	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

LARGE-IT1–THYM (OS)

Open the THYM breakdown →