LARGE-IT1

Across TCGA patient cohorts, LARGE-IT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,357 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LARGE-IT1-associated GO terms across cancer lineages are Regulation of RNA splicing, Peptidyl-lysine modification, and Regulation of nuclear-transcribed mRNA poly(A) tail shortening. Each is linked with LARGE-IT1 in more than 16 cancer types. Because this analysis shows association rather than direction, both LARGE-IT1-to-partner and partner-to-LARGE-IT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by LARGE-IT1-low versus LARGE-IT1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE-IT1→partner) and Y-score (partner→LARGE-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of RNA splicing →	+0.053	+0.304	<.001	<.001	3	17
STAD	Peptidyl-lysine modification →	+0.042	+0.218	<.001	<.001	3	16
LAML	Regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.056	+0.367	<.001	<.001	3	15
STAD	Protein-containing complex disassembly →	+0.041	+0.207	<.001	<.001	3	15
STAD	Telomere maintenance →	+0.038	+0.160	<.001	<.001	3	15
ESCA	Glycerophospholipid biosynthetic process →	+0.043	+0.320	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,357 associations by consensus.

Regulation of RNA splicing by LARGE-IT1 expression — ESCA

Explore this box plot interactively →