LAPTM4B

Across TCGA patient cohorts, LAPTM4B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAPTM4B-associated genes across cancer lineages are FOXO3a_pS318_S321, Myosin-IIa, and PI3K-p85. Each is linked with LAPTM4B in more than 1 cancer types. Because this analysis shows association rather than direction, both LAPTM4B-to-partner and partner-to-LAPTM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by LAPTM4B-low versus LAPTM4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4B→partner) and Y-score (partner→LAPTM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.180	-3.000	.012	.037	3	1
UCEC	Myosin-IIa →	+0.243	+3.007	.023	.019	3	1
UCEC	PI3K-p85 →	+0.294	+2.817	.015	.036	3	1
UCEC	Annexin-1 →	+0.690	+2.827	.023	.035	3	1
UCEC	C-Raf_pS338 →	-0.147	-3.000	.001	.037	3	1
UCEC	EGFR_pY1068 →	-0.398	-3.000	.006	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FOXO3a_pS318_S321 by LAPTM4B expression — UCEC

Explore this box plot interactively →