LAPTM4B

Across TCGA cell cohorts, LAPTM4B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,694 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LAPTM4B-associated GO terms across cancer lineages are Regulation of lysosomal membrane permeability, DNA-templated transcription initiation, and Transcription initiation at RNA polymerase II promoter. Each is linked with LAPTM4B in more than 16 cancer types. Because this analysis shows association rather than direction, both LAPTM4B-to-partner and partner-to-LAPTM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of lysosomal membrane permeability grouped by LAPTM4B-low versus LAPTM4B-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4B→partner) and Y-score (partner→LAPTM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of lysosomal membrane permeability →	+0.250	+1.964	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.063	+1.179	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.065	+1.230	<.001	.002	3	11
LARGE_INTESTINE	Nucleoside triphosphate metabolic process →	+0.072	+1.877	<.001	.002	3	11
KIDNEY	Nucleosome disassembly →	+0.161	+1.100	.003	.006	3	10
BLOOD_Myeloma	Aerobic respiration →	+0.075	+2.479	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,694 associations by consensus.

Regulation of lysosomal membrane permeability by LAPTM4B expression — LIVER

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