LAPTM4B

Across TCGA cell cohorts, LAPTM4B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAPTM4B-associated genes across cancer lineages are OOSP2, OR10J1, and GIMD1. Each is linked with LAPTM4B in more than 1 cancer types. Because this analysis shows association rather than direction, both LAPTM4B-to-partner and partner-to-LAPTM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP2 grouped by LAPTM4B-low versus LAPTM4B-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4B→partner) and Y-score (partner→LAPTM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OOSP2 →	+0.017	+4.781	<.001	.003	3	1
BREAST	OR10J1 →	+0.425	+4.781	<.001	.003	3	1
BLOOD_Leukemia	GIMD1 →	+0.034	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	1
LARGE_INTESTINE	GFRA4 →	+0.023	+3.930	<.001	.003	3	1
LARGE_INTESTINE	CPLX4 →	+0.044	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OOSP2 by LAPTM4B expression — BREAST

Explore this box plot interactively →