LAPTM4B

Across TCGA cell cohorts, LAPTM4B mutation is significantly associated with the mutation status of many other genes, with 2,748 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAPTM4B-associated genes across cancer lineages are NFIX, KMT5B, and DRD3. Each is linked with LAPTM4B in more than 2 cancer types. Because this analysis shows association rather than direction, both LAPTM4B-to-partner and partner-to-LAPTM4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFIX grouped by LAPTM4B-low versus LAPTM4B-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4B→partner) and Y-score (partner→LAPTM4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NFIX →	+4.857	+4.297	.009	.009	1	3
LUNG_NSCLC_LUAD	KMT5B →	+5.772	+5.772	.002	.002	1	3
BLOOD_Leukemia	DRD3 →	+5.285	+4.321	.005	.005	1	3
LUNG_NSCLC_LUAD	ADAMTS4 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	CERK →	+5.772	+5.772	.002	.002	1	3
LARGE_INTESTINE	FRYL →	+1.781	+3.602	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,748 associations by consensus.

NFIX by LAPTM4B expression — BREAST

Explore this box plot interactively →