LAPTM4A

Across TCGA patient cohorts, LAPTM4A protein abundance is significantly associated with the RNA expression of many other genes, with 6,781 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible LAPTM4A-associated genes across cancer lineages are ATP11A-AS1, PIF1, and BUB1B. Each is linked with LAPTM4A in more than 3 cancer types. Because this analysis shows association rather than direction, both LAPTM4A-to-partner and partner-to-LAPTM4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LAPTM4A versus ATP11A-AS1 in UCEC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4A→partner) and Y-score (partner→LAPTM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP11A-AS1 →	+0.984	+1.192	<.001	<.001	3	4
HNSC	PIF1 →	-1.016	-1.685	<.001	<.001	3	3
HNSC	BUB1B →	-0.983	-1.574	.002	.001	3	3
HNSC	CDC25C →	-0.930	-1.107	<.001	.007	3	3
LSCC	NKX2-1 →	+1.529	+0.871	<.001	<.001	3	3
LUAD	HPGDS →	+0.763	+1.497	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,781 associations by consensus.

LAPTM4A vs ATP11A-AS1 — UCEC

Explore this scatter interactively →