LAPTM4A

Across TCGA patient cohorts, LAPTM4A mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAPTM4A-associated genes across cancer lineages are p27_pT198, p90 RSK_pT359_S363, and Tuberin_pT1462. Each is linked with LAPTM4A in more than 1 cancer types. Because this analysis shows association rather than direction, both LAPTM4A-to-partner and partner-to-LAPTM4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by LAPTM4A-low versus LAPTM4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4A→partner) and Y-score (partner→LAPTM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.134	+3.000	.031	.037	3	1
UCEC	p90 RSK_pT359_S363 →	+0.263	+2.817	.024	.036	3	1
UCEC	Tuberin_pT1462 →	+0.314	+3.009	.018	.019	3	1
UCEC	p90 RSK →	+0.244	+3.013	.027	.019	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

p27_pT198 by LAPTM4A expression — UCEC

Explore this box plot interactively →