LAPTM4A

Across TCGA cell cohorts, LAPTM4A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,626 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LAPTM4A-associated GO terms across cancer lineages are Golgi vesicle transport, Protein localization to lysosome, and Endoplasmic reticulum mannose trimming. Each is linked with LAPTM4A in more than 13 cancer types. Because this analysis shows association rather than direction, both LAPTM4A-to-partner and partner-to-LAPTM4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi vesicle transport grouped by LAPTM4A-low versus LAPTM4A-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAPTM4A→partner) and Y-score (partner→LAPTM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Golgi vesicle transport →	+0.063	+0.980	<.001	<.001	3	13
OESOPHAGUS	Protein localization to lysosome →	+0.123	+1.198	.001	<.001	3	13
SKIN	Endoplasmic reticulum mannose trimming →	+0.103	+0.653	<.001	.001	2	14
BONE	Maintenance of protein location in cell →	+0.147	+1.300	<.001	<.001	3	13
BLOOD_Myeloma	ERAD pathway →	+0.087	+0.798	.006	.005	3	13
BONE	Cytokine production →	+0.248	+1.198	<.001	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,626 associations by consensus.

Golgi vesicle transport by LAPTM4A expression — CNS

Explore this box plot interactively →