LAP3

Across TCGA patient cohorts, LAP3 mutation is significantly associated with the RNA expression of many other genes, with 1,245 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAP3-associated genes across cancer lineages are MIR4462, RNU6ATAC34P, and LINC02559. Each is linked with LAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAP3-to-partner and partner-to-LAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4462 grouped by LAP3-low versus LAP3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAP3→partner) and Y-score (partner→LAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR4462 →	+0.463	+5.332	<.001	.002	3	2
KIRP	RNU6ATAC34P →	+0.349	+5.159	<.001	.007	3	2
CESC	LINC02559 →	+1.329	+5.342	<.001	.002	3	2
LIHC	GPHB5 →	+0.191	+5.108	<.001	.008	3	2
UCEC	RN7SL248P →	+0.048	+2.847	<.001	.008	3	2
LUSC	RNU6-1249P →	+0.163	+5.327	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,245 associations by consensus.

MIR4462 by LAP3 expression — COAD

Explore this box plot interactively →