LAMTOR5

Across TCGA patient cohorts, LAMTOR5 mutation is significantly associated with the RNA expression of many other genes, with 286 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMTOR5-associated genes across cancer lineages are RN7SL555P, MTCO3P42, and RNU6-273P. Each is linked with LAMTOR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMTOR5-to-partner and partner-to-LAMTOR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL555P grouped by LAMTOR5-low versus LAMTOR5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMTOR5→partner) and Y-score (partner→LAMTOR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL555P →	+0.418	+2.626	<.001	.006	3	2
UCEC	MTCO3P42 →	+0.090	+5.060	.004	.001	3	2
SKCM	RNU6-273P →	+0.431	+7.219	<.001	<.001	3	2
SKCM	NCKAP1P1 →	+0.030	+4.979	<.001	.009	3	2
BLCA	OR52M1 →	+0.042	+5.229	<.001	.002	3	2
BLCA	RNA5SP325 →	+0.190	+4.433	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 286 associations by consensus.

RN7SL555P by LAMTOR5 expression — UCEC

Explore this box plot interactively →