Across TCGA patient cohorts, LAMTOR4 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. CESC shows the largest number of these associations.

The most reproducible LAMTOR4-associated genes across cancer lineages are KRT8P47, IGHV3-54, and GPR50-AS1. Each is linked with LAMTOR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMTOR4-to-partner and partner-to-LAMTOR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMTOR4→partner) and Y-score (partner→LAMTOR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KRT8P47 →	+0.070	+3.488	<.001	.008	3	1
UCEC	IGHV3-54 →	+0.558	+3.334	<.001	.008	3	1
CESC	GPR50-AS1 →	+0.646	+4.409	<.001	.006	3	1
CESC	TRIM67-AS1 →	+0.049	+4.539	<.001	.008	3	1
CESC	PEX5L-AS1 →	+0.101	+4.705	<.001	.003	3	1
CESC	RNU6-506P →	+0.317	+5.144	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

LAMTOR4 survival (RNA) · tumor vs normal (RNA) · all LAMTOR4 data types