LAMTOR2

Across TCGA patient cohorts, LAMTOR2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,512 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible LAMTOR2-associated genes across cancer lineages are TTK, TOP2A, and SKA1. Each is linked with LAMTOR2 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMTOR2-to-partner and partner-to-LAMTOR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LAMTOR2 versus TTK in BRCA, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMTOR2→partner) and Y-score (partner→LAMTOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTK →	-1.191	-0.249	<.001	.001	3	5
LUAD	TOP2A →	-1.318	-0.258	<.001	<.001	3	5
HNSC	SKA1 →	-0.941	-0.217	<.001	<.001	3	5
HNSC	BUB1 →	-0.975	-0.279	<.001	<.001	3	5
GBM	BLM →	-0.799	-0.199	.002	.001	3	5
LUAD	SPAG5 →	-1.075	-0.248	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,512 associations by consensus.

LAMTOR2 vs TTK — BRCA

Explore this scatter interactively →