LAMTOR2

Across TCGA patient cohorts, LAMTOR2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMTOR2-associated genes across cancer lineages are RNASE11, DBF4P3, and HNRNPCL3. Each is linked with LAMTOR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMTOR2-to-partner and partner-to-LAMTOR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE11 grouped by LAMTOR2-low versus LAMTOR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMTOR2→partner) and Y-score (partner→LAMTOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNASE11 →	+0.033	+5.137	<.001	.003	3	1
UCEC	DBF4P3 →	+0.099	+5.660	<.001	.001	3	1
UCEC	HNRNPCL3 →	+0.107	+3.778	<.001	.007	3	1
UCEC	HBZ →	+0.295	+4.026	.002	.006	3	1
UCEC	MTL3P →	+0.319	+4.868	<.001	.004	3	1
UCEC	MIR3147 →	+0.552	+4.267	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RNASE11 by LAMTOR2 expression — UCEC

Explore this box plot interactively →