LAMP5

Across TCGA cell cohorts, LAMP5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMP5-associated genes across cancer lineages are ELOA3DP, DEFA3, and OR6Q1. Each is linked with LAMP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMP5-to-partner and partner-to-LAMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by LAMP5-low versus LAMP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP5→partner) and Y-score (partner→LAMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.023	+4.273	.003	.006	3	1
LARGE_INTESTINE	DEFA3 →	+0.070	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1
LUNG_NSCLC_LUAD	H4C6 →	+0.264	+4.628	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ELOA3DP by LAMP5 expression — LARGE_INTESTINE

Explore this box plot interactively →