LAMP3

Across TCGA patient cohorts, LAMP3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMP3-associated genes across cancer lineages are JNK2, Caspase-8, and 14-3-3_beta. Each is linked with LAMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAMP3-to-partner and partner-to-LAMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by LAMP3-low versus LAMP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP3→partner) and Y-score (partner→LAMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.284	+2.469	<.001	.010	3	2
UCEC	Caspase-8 →	-0.253	-2.558	.017	.010	3	2
UCEC	14-3-3_beta →	-0.102	-1.687	.016	.044	3	1
UCEC	eIF4E →	+0.197	+2.321	.027	.034	3	1
UCEC	Heregulin →	-0.125	-1.700	.016	.044	3	1
UCEC	Ku80 →	+0.302	+2.235	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

JNK2 by LAMP3 expression — UCEC

Explore this box plot interactively →