LAMP3

Across TCGA cell cohorts, LAMP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,757 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LAMP3-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Proteasomal ubiquitin-independent protein catabolic process, and Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Each is linked with LAMP3 in more than 11 cancer types. Because this analysis shows association rather than direction, both LAMP3-to-partner and partner-to-LAMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by LAMP3-low versus LAMP3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMP3→partner) and Y-score (partner→LAMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Response to endoplasmic reticulum stress →	+0.058	+2.141	.001	<.001	3	12
BREAST	Proteasomal ubiquitin-independent protein catabolic process →	+0.126	+1.810	<.001	<.001	3	10
OVARY	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.098	+1.814	<.001	<.001	3	10
BREAST	Regulation of protein ubiquitination →	+0.057	+1.410	<.001	.003	3	10
BREAST	Negative regulation of response to endoplasmic reticulum stress →	+0.062	+1.356	.002	<.001	3	10
LARGE_INTESTINE	Regulation of protein deubiquitination →	+0.115	+1.095	<.001	.005	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,757 associations by consensus.

Response to endoplasmic reticulum stress by LAMP3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →