LAMC1

Across TCGA pan-cancer cohorts, LAMC1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LAMC1 data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LAMC1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LAMC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, BLCA, and UCEC are the cancer types where LAMC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.348	0.606	.021	11	view →
BLCA	DFS	Median	IV	0.111	0.472	.002	6	view →
UCEC	DFS	Median	All	0.746	0.635	.045	6	view →
LUSC	OS	Median	II,III,IV	0.216	0.422	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LAMC1–HNSC (DFS)

Open the HNSC breakdown →