LAMC1

Across TCGA pan-cancer cohorts, LAMC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LAMC1 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LAMC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LAMC1 expression acts as an unfavorable survival marker, although some lineages such as OV and CCRCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where LAMC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.344	1.000	.009	17	view →
LUAD	OS	Quartile	III,IV	0.419	0.842	.015	13	view →
LSCC	DFS	Tertile	II,III,IV	0.879	1.000	.028	5	view →
OV	DFS	Median	All	1.000	0.719	.048	4	view →
CCRCC	DFS	Tertile	III,IV	0.860	0.595	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LAMC1–HNSC (OS)

Open the HNSC breakdown →