LAMB1

Across TCGA cell cohorts, LAMB1 mutation is significantly associated with the RNA expression of many other genes, with 521 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMB1-associated genes across cancer lineages are OPN1MW, GPR182, and ELOA3CP. Each is linked with LAMB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMB1-to-partner and partner-to-LAMB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPN1MW grouped by LAMB1-low versus LAMB1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMB1→partner) and Y-score (partner→LAMB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OPN1MW →	+0.035	+5.169	<.001	.005	3	2
LUNG_NSCLC_LUAD	GPR182 →	+0.314	+3.404	<.001	.004	2	3
BLOOD_Leukemia	ELOA3CP →	+0.121	+3.789	<.001	.002	3	2
LARGE_INTESTINE	SCML2 →	+1.096	+3.212	.002	.006	3	2
SOFT_TISSUE	TIMD4 →	+0.237	+4.222	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	ANHX →	+0.036	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 521 associations by consensus.

OPN1MW by LAMB1 expression — BREAST

Explore this box plot interactively →