LAMA5

Across TCGA cell cohorts, LAMA5 mutation is significantly associated with the RNA expression of many other genes, with 1,805 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMA5-associated genes across cancer lineages are GCAT, METTL21A, and ACYP1. Each is linked with LAMA5 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMA5-to-partner and partner-to-LAMA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by LAMA5-low versus LAMA5-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA5→partner) and Y-score (partner→LAMA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GCAT →	+1.164	+1.944	<.001	.008	3	4
LARGE_INTESTINE	METTL21A →	+0.508	+1.332	.001	.001	3	4
LARGE_INTESTINE	ACYP1 →	+0.404	+2.000	.005	.004	3	4
LARGE_INTESTINE	DTWD2 →	+0.573	+2.807	<.001	<.001	3	4
LARGE_INTESTINE	C15orf61 →	+0.266	+1.415	.007	.006	2	5
LARGE_INTESTINE	ATXN3 →	+0.445	+2.087	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,805 associations by consensus.

GCAT by LAMA5 expression — STOMACH

Explore this box plot interactively →