Across TCGA pan-cancer cohorts, LAMA4-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LAMA4-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher LAMA4-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LAMA4-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and SKCM show a favorable association.

ACC, STAD, and MESO are the cancer types where LAMA4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.404	0.748	<.001	154	view →
STAD	OS	Median	All	0.365	0.680	<.001	63	view →
MESO	DFS	Tertile	All	0.457	0.269	.005	51	view →
KIRC	DFS	Median	II,III,IV	0.427	0.622	<.001	41	view →
COAD	OS	Tertile	III,IV	0.605	0.850	.003	40	view →
HNSC	OS	Median	III,IV	0.550	0.772	.002	38	view →
BRCA	DFS	Quartile	II,III,IV	0.852	0.920	.009	27	view →
SKCM	OS	Median	IV	0.867	0.244	.006	27	view →
DLBC	OS	Median	III,IV	0.175	0.874	.025	24	view →
PAAD	DFS	Quartile	All	0.179	0.417	.003	23	view →
SARC	DFS	Median	All	0.626	0.436	.008	10	view →
LUAD	DFS	Quartile	IV	0.248	0.896	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

Exploration

Same gene, other analysis: LAMA4-AS1 tumor-vs-normal RNA expression · all LAMA4-AS1 data types